In this study, acute CO poisoning was induced in Sprague-Dawley rats by exposing them to 1000 ppm CO in air for 40 min and then 3000 ppm CO for another 20 min until they lost consciousness. Hydrogen-rich saline (10 mL/kg) or normal saline (NS) (10 mL/kg, peritoneally) was administered immediately and again at 8 h and 16 h after CO insult. More Nissl-stained cells were observed in CO …
Hydrogen reduces immune-mediated brain injury
This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin sheath were observed by electron microscope. Neuron loss was assessed by Nissl staining. Antioxidant capacities were …
Hydrogen-rich saline protects brain from acute carbon monoxide poisoning
Studies have shown that inhalation of hydrogen gas, which acts as an antioxidant, can protect the brain against free radicals in rats with ischemia-reperfusion. The neuronal damage caused by acute carbon monoxide (CO) poisoning is partly free radical mediated. We hypothesize that hydrogen may prevent neurological damage from CO poisoning. This study is designed to test whether hydrogen (H(2))-rich saline …
Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning?
Hydrogen is a major component of interstellar space and the fuel that sustains the stars. However, it is seldom regarded as a therapeutic gas. A recent study provided evidence that hydrogen inhalation exerted antioxidant and anti-apoptotic effects and protected the brain against ischemia-reperfusion injury by selectively reducing hydroxyl radical and peroxynitrite. It has been known that the mechanisms underlying the …
Hydrogen-rich saline reduces neurologic sequelae in experimental CO toxicity
Authors investigated the feasibility and efficacy of hydrogen-rich saline therapy on delayed neurologic sequelae in a rat model of severe acute carbon monoxide (CO) poisoning. Design was controlled animal study at the University research laboratory for Diving Medicine, with Sprague-Dawley rats weighing 250 ± 20 g. The rats were exposed to 1000 ppm CO in air for 40 min and …