Pemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1/3 antibodies in P-ILD pathogenesis and evaluated the therapeutic potential of molecular hydrogen (H2). Using a BALB/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, …
Hydrogen-rich water reduces muscle damage
Physical activity significantly increases the production of reactive oxygen species in the body. Molecular hydrogen has been shown to have safe and effective antioxidant properties on athletes. However, research on elite athletes is scarce. A randomized, double-blinded, placebo-controlled trial was conducted with 22 female elite athletes participating in handball and skeleton sports. The first group received hydrogen-rich water (HRW)-generating tablets, …
Hydrogen-rich water protects against encephalopathy
Hepatic encephalopathy (HE), a neuropsychiatric complication secondary to liver cirrhosis and hepatic failure, represents the leading cause of mortality in end-stage liver disease. While hyperammonemia remains the central pathogenic factor in HE progression, emerging evidence implicates oxidative stress, neuroinflammation, and neuronal apoptosis as critical synergistic contributors to HE pathogenesis. Hydrogen-rich water, known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, has …
Hydrogen ameliorates steroid-associated osteonecrosis
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deteriorated trabecular architecture, increases osteoblast numbers and the bone …
Hydrogen alleviates obliterative airway disease
Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function in a heterotopic tracheal allograft mouse model of obliterative airway disease. Obliterative airway …
Hydrogen water for chronic fatigue syndrome
Given the absence of restorative treatments for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), testing of alternative interventions may offer new options to help these debilitated individuals. To explore in an 8-week pilot randomized trial the potential benefit of two non-invasive treatments, hydrogen water (H2) and app-based heart rate variability biofeedback (HRV-BF), for the symptoms and functional limitations in ME/CFS. A three-arm, …
Potential of hydrogen in Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing a key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) in a zebrafish AD model. Zebrafish were exposed to aluminum chloride to induce AD-like …
Hydrogen for muscular endurance and fatigue
Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained individuals have not been well characterized. This study aimed to …
Hydrogen-rich water in hyperuricemia
Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits. A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia. The Placebo group consumed three bottles of ordinary drinking water (330 mL …
Hydrogen reduces fatty acid-induced lipid accumulation
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention due to its efficiency in neutralizing harmful reactive oxygen species (ROS) and …