Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases. We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Prospective study. In total, 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 min in 10 patients with asthma and 10 patients …
Hydrogen protects against cigarette smoke-induced COPD
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with limited treatment options. Hydrogen (H2) has been shown to be anti-oxidative and anti-inflammatory. This study aimed to evaluate the beneficial effects of H2 inhalation on COPD development in mice. A COPD mouse model was established in male C57BL mice by cigarette smoke (CS) exposure. The H2 intervention was administered …
Hydrogen slows the development of COPD-like lung disease after smoke exposure
Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary disease caused by harmful gases or particles. Recent studies have shown that 2% hydrogen or hydrogen water is effective in the treatment and prevention of a variety of diseases. This study investigated the beneficial effects and the possible mechanisms of different hydrogen concentrations on COPD. A rat COPD model was established …
Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease induced by tobacco smoke has been regarded as a great health problem worldwide. The purpose of this study is to evaluate the protective effect of hydrogen-rich saline, a novel antioxidant, on chronic obstructive pulmonary disease and explore the underlying mechanism. Sprague-Dawley rats were made chronic obstructive pulmonary disease models via tobacco smoke exposure for 12 weeks …
Hydrogen-rich water prevents cigarette smoke-induced pulmonary emphysema
Chronic obstructive pulmonary disease (COPD) is predominantly a cigarette smoke (CS)-triggered disease with features of chronic systemic inflammation. Oxidants derived from CS can induce DNA damage and stress-induced premature cellular senescence in the respiratory system, which play significant roles in COPD. Therefore, antioxidants should provide benefits for the treatment of COPD; however, their therapeutic potential remains limited owing to the …
Hydrogen therapy may be a novel and effective treatment for COPD
The protective effect of hydrogen (H2) on ROS-induced diseases has been proved by many researches, which demonstrated that through eliminating •OH and •ONOO–, H2 could effectively attenuate lipid and DNA peroxidation, improve cellular antioxidant capacity, and then protect cells against oxidant damage. Most of free radicals in human body are ROS, including O2•–,•OH, H2O2, NO•,•ONOO–, and so on. Under normal …