Hydrogen (H2) and carbon monoxide (CO) gas are both reported to reduce reactive oxygen species and alleviate tissue ischemia-reperfusion (I-R) injury. The present study was conducted to evaluate the effects of a mixture of H2 gas and CO gas (dual gas) in comparison with hydrogen gas (H2: 2%) alone on I-R renal injury (composition of dual gas; N2: 77.8%; O2: …
Lung inflation with hydrogen reduced lung injury
Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)’s anti-inflammatory effect or hydrogen (H2)’s anti-oxidant effect. In this study, the effects of lung inflation with CO, H2, or both during the cold ischemia phase on graft function were observed. Rat donor lungs, inflated with 40% oxygen (control group), 500ppm CO (CO group), 3% H2 (H2 group) or 500ppm …
Neuroprotective effect of hydrogen-rich saline
In this study, acute CO poisoning was induced in Sprague-Dawley rats by exposing them to 1000 ppm CO in air for 40 min and then 3000 ppm CO for another 20 min until they lost consciousness. Hydrogen-rich saline (10 mL/kg) or normal saline (NS) (10 mL/kg, peritoneally) was administered immediately and again at 8 h and 16 h after CO insult. More Nissl-stained cells were observed in CO …
Hydrogen reduces immune-mediated brain injury
This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin sheath were observed by electron microscope. Neuron loss was assessed by Nissl staining. Antioxidant capacities were …
Hydrogen-rich saline protects brain from acute carbon monoxide poisoning
Studies have shown that inhalation of hydrogen gas, which acts as an antioxidant, can protect the brain against free radicals in rats with ischemia-reperfusion. The neuronal damage caused by acute carbon monoxide (CO) poisoning is partly free radical mediated. We hypothesize that hydrogen may prevent neurological damage from CO poisoning. This study is designed to test whether hydrogen (H(2))-rich saline …
Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning?
Hydrogen is a major component of interstellar space and the fuel that sustains the stars. However, it is seldom regarded as a therapeutic gas. A recent study provided evidence that hydrogen inhalation exerted antioxidant and anti-apoptotic effects and protected the brain against ischemia-reperfusion injury by selectively reducing hydroxyl radical and peroxynitrite. It has been known that the mechanisms underlying the …
Amelioration of rat cardiac ischemia injury with inhaled hydrogen
Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use. This study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Syngeneic heterotopic heart transplantation was performed in rats after 6 or 18 hours of cold ischemia in Celsior …
Hydrogen-rich saline reduces neurologic sequelae in experimental CO toxicity
Authors investigated the feasibility and efficacy of hydrogen-rich saline therapy on delayed neurologic sequelae in a rat model of severe acute carbon monoxide (CO) poisoning. Design was controlled animal study at the University research laboratory for Diving Medicine, with Sprague-Dawley rats weighing 250 ± 20 g. The rats were exposed to 1000 ppm CO in air for 40 min and …