Gaseous hydrogen improves myocardial dysfunction

In Animal studies, Cardiovascular by CHESS

Immediate inhalation of hydrogen (H2) has been demonstrated to improve post-resuscitation (PR) myocardial dysfunction. In this study, the authors investigated the effects of delayed treatments with H2 on myocardial dysfunction in a porcine model of cardiac arrest (CA). Twenty male pigs weighing 39 ± 2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 10 min. All the animals were successfully resuscitated manually and then randomized into two groups: delayed inhalation of H2 (DH group) or continuous inhalation of room air (C group). Animals in DH group were ventilated with 2% H2/21% oxygen from PR 2h till PR 4h. Left ventricle pressure (LVP) was recorded continuously and cardiac output (CO) was measured by the thermo-dilution technique at baseline (BL) and then hourly after resuscitation for 6 hours. Serum levels of troponin T (Tn T) and N-terminal probrain natriuretic peptide (NTpro-BNP) were measured by ELISA at BL, PR 180 min and PR 360 min. Deteriorations in maximum rate of LVP increase (dp/dtmax), maximum rate of LVP decline (-dp/dtmax) and CO were observed in all the animals after PR 4 h. However, better dp/dtmax, -dp/dtmax and cardiac output were achieved in the hydrogen group after PR 5h when compared with the C group. Although levels of both Tn T and NTpro-BNP in serum increased after resuscitation, they were significantly lower in animals of DH group in comparison with C group. Delayed treatment of H2 attenuates myocardial injury and improves myocardial dysfunction after resuscitation.

Link to Full Text

Yang Z, Yu T, Wen C, et al. Delayed inhalation of hydrogen improves myocardial dysfunction in a porcine model of cardiac arrest and cardiopulmonary resuscitation circulation. 2016;134:A12002.