Hydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI). The authors designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI). The 20 patients with an initial diagnosis of STEMI were assigned to either an HI group (1.3% H2with 26% oxygen) or …
Efficacy of inhaled hydrogen on neurological outcomes following brain ischemia during post-cardiac arrest
Hydrogen gas inhalation (HI) improved survival and neurological outcomes in an animal model of post-cardiac arrest syndrome (PCAS). The feasibility and safety of HI for patients with PCAS was confirmed in a pilot study. The objective of this study is to evaluate the efficacy of HI for patients with PCAS. The efficacy of inhaled HYdrogen on neurological outcome following BRain …
Hydrogen gas inhalation in acute cerebral infarction
Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized controlled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, the authors evaluate the H2 treatment on acute cerebral infarction. Through this randomized controlled …
Effects of hydrogen rich water on prolonged intermittent exercise
Recent studies showed a positive effect of Hydrogen Rich Water (HRW) intake on acid-basic homeostasis at rest. The authors investigated 2-weeks of HRW intake on repeated sprint performance and acid-base status during prolonged intermittent cycling exercise. In a cross over single-blind protocol, eight trained male cyclists (age [mean ± SD] 41±7 years, body mass 72.3±4.4 kg, height 1.77±0.04 m, maximal …
Hydrogen-rich water positively affects exercise capacity in mid-age overweight women
Molecular hydrogen (H2) improves body composition, metabolic profiles and mitochondrial function in overweight women, yet no studies so far evaluated the effectiveness of H2 for improving exercise capacity in this population. The authors examined the effects of 28-days supplementation with 1 L per day of hydrogen-rich water (HRW) on exercise capacity and quality of life in overweight mid-age women. Twelve …
Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with chemotherapy
The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among …
Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life
Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several …
Molecular hydrogen positively affected post-exercise recovery
Molecular hydrogen (H2) recently appeared as a novel and safe ergogenic agent that might have beneficial effects in athletes. However, no information is available concerning the impact of H2 on post-exercise recovery indices. The purpose of this study was to determine the effects of pre-exercise H2 administration on post-exercise heart rate and blood lactate responses in judo athletes. Five athletes …
Hydrogen gas for post-cardiac arrest syndrome
Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target …
Improvement of psoriasis-associated arthritis by treatment with molecular hydrogen
Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)-6, and IL-17. Effective treatments, including pathogenesis-based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been investigated, it remains to be fully elucidated; ROS-targeted therapeutic strategies …