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Hydrogen reduces inflammatory responses and prevents apoptosis

In Human studies, Inflammation by CHESS

The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. The authors aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1.5 L/d of HW (n = 20) or …

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Hydrogen-rich water attenuates pre-diabetic DNA oxidative injuries

In Human studies, Metabolism by CHESS

Hydrogen-rich water is conventionally prepared by direct current-electrolysis, but has been not or scarcely prepared by alternating current (AC)-electrolysis. The AC preparations from tap water for 20-30 minutes exhibit a dissolved hydrogen concentration of 1.55 mg/L, which was close to the theoretical maximum value of 1.6 mg/L. These preparations also displayed an oxidation-reduction potential of -270 mV (tap water: +576 …

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Hydrogen-rich water and muscular soreness

In Exercise, Human studies by CHESS

High-intensity eccentric exercise can cause a delayed onset of muscle soreness (DOMS), a short-term condition characterized by muscle damage and tenderness that might hold up recovery and jeopardize exercise routine. Previous studies indicated that hydrogen-rich water (HRW) might be a helpful topical intervention to boost recovery in musculoskeletal medicine, yet no data are available concerning the effectiveness and safety of …

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Hydrogen in patients with chronic graft-versus-host-disease

In Inflammation, Skin by CHESS

Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We hypothesized that hydrogen may exert therapeutic effects on cGVHD patients with few side effects. A prospective open-label phase 2 study of hydrogen was conducted. Patients received hydrogen-rich water 4ml/kg …

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Hydrogen-rich water for acute ankle sprain

In Exercise, Human studies, Inflammation by CHESS

We analysed the effects of an experimental novel protocol of intensive hydrotherapy with hydrogen-rich water (HRW) on injury recovery in athletic men who suffered an acute ankle sprain (AAS) and compared it with a RICE protocol (rest, ice, compression, elevation). Professional athletes (age 23.7 ± 4.0 years; weight 78.6 ± 5.7 kg, height 182.5 ± 4.3 cm; professional experience 5.9 …

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Heat-retention effects of hydrogen-rich water bath

In Human studies, Skin by CHESS

Hydrogen-rich water bath devices are commercially available, but have been scarcely clarified for heat-retention effects. In this study, heat-retention effects of hydrogen-rich water bath were assessed by thermographic clinical trials, which employed twenty-four healthy subjects. The thermograms indicated that, under the same conditions (41 °C, 10-min bathing), hydrogen-rich water bath (hydrogen concentrations: 185-548 μg/L; oxidation-reduction potentials: -167 to -91 mV, …

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Breathing hydrogen-oxygen mixture decreases inspiratory effort

In Cardiovascular, Human studies by CHESS

Hydrogen-oxygen mixture (H2-O2) may reduce airway resistance in patients with acute severe tracheal stenosis, yet data supporting the clinical use of H2-O2 are insufficient. The authors evaluated the efficacy and safety of breathing H2-O2 in acute severe tracheal stenosis. Thirty-five consecutive patients with severe acute tracheal stenosis were recruited in this prospective self-control study. Air, H2-O2 and O2 inhalation was …

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Inhalation of hydrogen in Parkinson’s disease

In Human studies, Nervous system by CHESS

Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. The authors evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor …

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Hydrogen-controlled cancer

In Cancer, Human studies by CHESS

Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. The authors conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation …

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Hydrogen-rich water affects antioxidant activity and gut flora in soccer players

In Exercise, Human studies by CHESS

Expending a considerable amount of physical energy inevitably leads to fatigue during both training and competition in football. An increasing number of experimental findings have confirmed the relationship between the generation and clearance of free radicals, fatigue, and exercise injury. Recently, hydrogen was identified as a new selective antioxidant with potential beneficial applications in sports. The present study evaluated the …