The combination of H₂ gas inhalation and H₂-enriched dialysate offers a novel and promising approach to managing oxidative stress and improving the quality of life in patients on HD. However, further research is essential to optimize treatment protocols, ensure safety, and develop comprehensive clinical guidelines for the widespread adoption of this therapy. Link to Full Text Nakazawa R, Nagami S, …
Hydrogen water as useful mouthwash
Previous studies have demonstrated the inhibitory effect of hydrogen-rich water on biofilm formation. However, hydrogen-rich electrolyzed water (HEW) has not been evaluated as mouthwash, despite being economical, convenient, and biologically safe. We assessed the antibiofilm effects of HEW on Streptococcus mutans and its potential as a mouthwash. The effect of HEW on S. mutans growth was assessed by measuring bacterial …
Hydrogen-rich water reduces muscle damage
Physical activity significantly increases the production of reactive oxygen species in the body. Molecular hydrogen has been shown to have safe and effective antioxidant properties on athletes. However, research on elite athletes is scarce. A randomized, double-blinded, placebo-controlled trial was conducted with 22 female elite athletes participating in handball and skeleton sports. The first group received hydrogen-rich water (HRW)-generating tablets, …
Hydrogen water for chronic fatigue syndrome
Given the absence of restorative treatments for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), testing of alternative interventions may offer new options to help these debilitated individuals. To explore in an 8-week pilot randomized trial the potential benefit of two non-invasive treatments, hydrogen water (H2) and app-based heart rate variability biofeedback (HRV-BF), for the symptoms and functional limitations in ME/CFS. A three-arm, …
Hydrogen for muscular endurance and fatigue
Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained individuals have not been well characterized. This study aimed to …
Hydrogen-rich water in hyperuricemia
Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits. A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia. The Placebo group consumed three bottles of ordinary drinking water (330 mL …
Hydrogen, gut microbiome and opioid addiction
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechanism of gut microbiota base …
Hydrogen inhalation for reactive oxygen stress
Reactive Oxygen Species (ROS) play a key role in physiological processes. However, the imbalance between ROS and antioxidants in favor of the former causes oxidative stress linked to numerous pathologies. Due to its unique attributes, including distinguished permeability and selective antioxidant capability, molecular hydrogen (H2) has become an essential therapeutic agent. Hydrogen Inhalation Therapy (HIT) has come to light as …
Hydrogen inhalation ameliorates airway inflammation
Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases. We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Prospective study. In total, 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 min in 10 patients with asthma and 10 patients …
Hydrogen against lung cancer progression
Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms or the adverse events of drugs. Twenty patients who refused drug treatment were assigned equally and randomly to a hydrogen …