View Post

Hydrogen-rich saline for neuropathic pain

In Animal studies, Nervous system by CHESS

Neuropathic pain is a chronic and intractable pain, with very few effective analgesics. It involves an impaired cell autophagy process. Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction. The authors investigated the relationship between HRS and cell autophagy in a neuropathic pain model generated by …

View Post

Hydrogen-rich water ameliorates autistic-like behavioral abnormalities

In Animal studies, Nervous system by CHESS

Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administration on valproic acid (VPA)-induced autistic-like …

View Post

Molecular hydrogen inhalation attenuates postoperative cognitive impairment

In Animal studies, Nervous system by CHESS

Postoperative cognitive decline is a major clinical problem with high morbidity and mortality after surgery. Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. In this study, the authors hypothesized that H2 treatment could ameliorate the development of cognitive impairment following surgery. Adult male rats were subjected …

View Post

Hydrogen-rich saline attenuates brain injury induced by cardiopulmonary bypass

In Animal studies, Cardiovascular, Nervous system by CHESS

Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway. A rat CPB model and an in vitro cell hypoxia model were established. After HRS …

View Post

Hydrogen attenuates brain injury after cardiac arrest

In Animal studies, Cardiovascular, Nervous system by CHESS

Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest. The rats were randomly divided …

View Post

Hydrogen attenuates cognitive impairment via inhibition of mitochondrial dysfunction

In Animal studies, In vitro studies, Nervous system by CHESS

The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This study aimed to investigate the protective effect of hydrogen, …

View Post

Hydrogen-rich saline and postoperative cognitive dysfunction

In Animal studies, Liver, Nervous system by CHESS

This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24 each): control group (group C), hydrogen-rich saline group (group H), POCD group (group P), and POCD + hydrogen-rich saline group (group PH). …

View Post

Hydrogen affects the morphine withdrawal symptoms

In Animal studies, Nervous system, Uncategorized by CHESS

Hydrogen therapy is a new medical approach for a wide range of diseases. The effects of hydrogen on central nervous system-related diseases have recently become increasingly appreciated, but little is known about whether hydrogen affects the morphine withdrawal process. This study aims to investigate the potential effects of hydrogen-rich saline (HRS) administration on naloxone-precipitated withdrawal symptoms and morphine withdrawal-induced anxiety-like …

View Post

Effect of hydrogen-rich water on the CD34 expression in brain tissue of rats with brain injury

In Animal studies, Nervous system by CHESS

The main aim of this study was to observe the effect of hydrogen-rich water on the CD34 expression and angiogenesis in lesion boundary brain tissue of rats with traumatic brain injury (TBI). A total of 54 adult male Sprague-Dawley (SD) rats were divided into three groups by random number table: namely sham-operated group (sham group), trauma group (TBI group), and …

View Post

Hydrogen-rich saline for hepatectomy-induced cognitive dysfunction

In Animal studies, Liver, Nervous system by CHESS

This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24 each): control group (group C), hydrogen-rich saline group (group H), POCD group (group P), and POCD + hydrogen-rich saline group (group PH). …