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Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline

In Animal studies, Lung by CHESS

Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking (CS) is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the present study authors investigated …

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Hydrogen reduces airway remodeling in asthma

In Animal studies, Lung by CHESS

Recent studies suggest that hydrogen has great therapeutic and prophylactic potential against organ injury caused by oxidative stress and inflammation. Here authors investigated the effect of hydrogen-rich saline on airway inflammation and remodeling in a murine model of asthma. Asthma was induced by ovalbumin (OVA) sensitization and challenge. Then mice were treated with normal saline or hydrogen-rich saline at low …

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Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits

In Animal studies, Lung by CHESS

Hydrogen gas, an antioxidant agent, was found to protect against cerebral and myocardial ischemia-reperfusion (I/R) injury. In the present study, authors investigated the effect of hydrogen-rich saline (HRS) on the I/R-induced lung injury. Left lung of male New Zealand White rabbits rendered normothermic ischemia for 60 min and reperfused for up to 240 min. Treated animals received intraperitoneal injection of …

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Protective effects of hydrogen-rich saline on pulmonary hypertension

In Animal studies, Lung by CHESS

Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. In male Sprague-Dawley rats, pulmonary hypertension was …

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Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries

In Animal studies, Lung by CHESS

Protective effects of saturated hydrogen (H(2)) saline on cardiac ischaemia-reperfusion (I/R) injury have been demonstrated previously. This study was designed to show that hydrogen-rich saline is protective in preventing lung I/R injury in rats. Adult male Sprague-Dawley rats underwent 45 min occlusion of the right lung roots and 120 min reperfusion. Rats were divided randomly into three groups: sham-operated control …

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Protection of oral hydrogen water as an antioxidant on pulmonary hypertension

In Animal studies, Lung by CHESS

This study aimed to explore the protective effect of hydrogen as an antioxidant on monocrotaline (MCT)-induced pulmonary hypertension (PH). Forty-eight SD rats were equally randomized into four groups: SHAM group, MCT group, MCT+Oral-H2 group and MCT+Inj-H2 group. The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT group were significant higher …

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Hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, several studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H₂ ameliorates lung injury remain unclear. In the current study, authors investigated whether H₂ or …

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Hydrogen gas reduces hyperoxic lung injury and improved blood oxygenation

In Animal studies, Lung by CHESS

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme …

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Consumption of hydrogen water reduces paraquat-induced acute lung injury

In Animal studies, Lung by CHESS

Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a contributor to paraquat-induced acute lung injury. Recent studies have reported that consumption of water with dissolved molecular hydrogen to a saturated level (hydrogen water) prevents oxidative stress-induced diseases. Here, authors investigated whether consumption of saturated hydrogen saline protects rats against paraquat-induced acute lung injury. …

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Hydrogen therapy attenuates irradiation-induced lung damage

In Animal studies, Lung by CHESS

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from damaging effects of irradiation, we investigated the possibility …