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Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury

In Animal studies, Gut, Lung by CHESS

This study evaluated the effects of combined early fluid resuscitation and hydrogen inhalation on septic shock-induced lung and intestine injuries. Wistar male rats were randomly divided into four groups: control group (Group A, n = 15); septic shock group (Group B, n = 15); early fluid resuscitation-treated septic shock group (Group C, n = 15); and early fluid resuscitation and …

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Hydrogen exerts protective effects on lung grafts

In Animal studies, Lung by CHESS

The process of brain death induces acute lung injury in donors and aggravates ischemia-reperfusion injury (IRI) in grafts. Hydrogen, a new anti-oxidant, attenuates IRI in several organ transplant models. Authors examined whether 2% inhaled hydrogen would show favorable effects on lung grafts from brain-dead donor rats. Brain-dead donor rats inhaled mixed gases with either 50% oxygen and 50% nitrogen or …

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Hydrogen inhalation ameliorates acute lung injury

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is a serious illness, the incidence and mortality of which are very high. Free radicals, such as hydroxyl radicals (OH) and peroxynitrite (ONOO(-)), are considered to be the final causative molecules in the pathogenesis of ALI. Hydrogen, a new antioxidant, can selectively reduce OH and ONOO(-). In the present study, we investigated the hypothesis that hydrogen …

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Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline

In Animal studies, Lung by CHESS

Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking (CS) is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the present study authors investigated …

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Hydrogen reduces airway remodeling in asthma

In Animal studies, Lung by CHESS

Recent studies suggest that hydrogen has great therapeutic and prophylactic potential against organ injury caused by oxidative stress and inflammation. Here authors investigated the effect of hydrogen-rich saline on airway inflammation and remodeling in a murine model of asthma. Asthma was induced by ovalbumin (OVA) sensitization and challenge. Then mice were treated with normal saline or hydrogen-rich saline at low …

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Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits

In Animal studies, Lung by CHESS

Hydrogen gas, an antioxidant agent, was found to protect against cerebral and myocardial ischemia-reperfusion (I/R) injury. In the present study, authors investigated the effect of hydrogen-rich saline (HRS) on the I/R-induced lung injury. Left lung of male New Zealand White rabbits rendered normothermic ischemia for 60 min and reperfused for up to 240 min. Treated animals received intraperitoneal injection of …

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Protective effects of hydrogen-rich saline on pulmonary hypertension

In Animal studies, Lung by CHESS

Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. In male Sprague-Dawley rats, pulmonary hypertension was …

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Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries

In Animal studies, Lung by CHESS

Protective effects of saturated hydrogen (H(2)) saline on cardiac ischaemia-reperfusion (I/R) injury have been demonstrated previously. This study was designed to show that hydrogen-rich saline is protective in preventing lung I/R injury in rats. Adult male Sprague-Dawley rats underwent 45 min occlusion of the right lung roots and 120 min reperfusion. Rats were divided randomly into three groups: sham-operated control …

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Protection of oral hydrogen water as an antioxidant on pulmonary hypertension

In Animal studies, Lung by CHESS

This study aimed to explore the protective effect of hydrogen as an antioxidant on monocrotaline (MCT)-induced pulmonary hypertension (PH). Forty-eight SD rats were equally randomized into four groups: SHAM group, MCT group, MCT+Oral-H2 group and MCT+Inj-H2 group. The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT group were significant higher …

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Hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, several studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H₂ ameliorates lung injury remain unclear. In the current study, authors investigated whether H₂ or …