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Hydrogen-rich water ameliorates bronchopulmonary dysplasia

In Animal studies, Lung by CHESS

Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. The authors made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at …

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Hydrogen improves lung function in sepsis

In Animal studies, Inflammation, Lung by CHESS

Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality. It has been reported that hydrogen-rich saline (HRS) has protective effects against sepsis-related lung injury. In this study, we hypothesized that the protective effect occurred by preserving the expression of AQP1 …

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Molecular hydrogen with NO provide enhanced therapeutic efficacy in acute lung injury

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Inhaled nitric oxide (NO) has been reported to ameliorate ALI. However, reactive nitrogen species produced by NO can cause lung injury. Because hydrogen gas (H2) is reported to eliminate peroxynitrite, it is expected to reduce the adverse effects of NO. Moreover, we have …

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Hydrogen-rich saline ameliorates acute lung injury

In Animal studies, Lung by CHESS

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. The experiments exhibited that gas exchange dysfunction and …

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Effects of three hydrogen-rich liquids on lung injury-induced hemorrhagic shock

In Animal studies, Lung by CHESS

Hydrogen-rich saline provides a high concentration of hydrogen, which selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. Authors investigated the protective effects and mechanisms of three different hydrogen-rich liquid resuscitation preparations on lung injury-induced uncontrolled-hemorrhagic shock (UHS) in rats. A UHS rat model was prepared using the method of Capone et al. of arterial bleeding …

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Hydrogen-rich saline exerts protective effects in acute lung injury induced by smoke inhalation

In Animal studies, Lung by CHESS

The present study explored the protective effects of hydrogen-rich saline on rats with smoke inhalation injury. 36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n = 12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS). 30 min after injury, normal saline and hydrogen-rich saline …

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Hydrogen-rich saline ameliorates lung injury and puncture-induced sepsis

In Animal studies, Inflammation, Lung by CHESS

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Our experiments exhibited that gas …

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Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury

In Animal studies, Gut, Lung by CHESS

This study evaluated the effects of combined early fluid resuscitation and hydrogen inhalation on septic shock-induced lung and intestine injuries. Wistar male rats were randomly divided into four groups: control group (Group A, n = 15); septic shock group (Group B, n = 15); early fluid resuscitation-treated septic shock group (Group C, n = 15); and early fluid resuscitation and …

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Hydrogen exerts protective effects on lung grafts

In Animal studies, Lung by CHESS

The process of brain death induces acute lung injury in donors and aggravates ischemia-reperfusion injury (IRI) in grafts. Hydrogen, a new anti-oxidant, attenuates IRI in several organ transplant models. Authors examined whether 2% inhaled hydrogen would show favorable effects on lung grafts from brain-dead donor rats. Brain-dead donor rats inhaled mixed gases with either 50% oxygen and 50% nitrogen or …

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Hydrogen inhalation ameliorates acute lung injury

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is a serious illness, the incidence and mortality of which are very high. Free radicals, such as hydroxyl radicals (OH) and peroxynitrite (ONOO(-)), are considered to be the final causative molecules in the pathogenesis of ALI. Hydrogen, a new antioxidant, can selectively reduce OH and ONOO(-). In the present study, we investigated the hypothesis that hydrogen …