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Beneficial effects of hydrogen inhalation in allergic rhinitis

In Animal studies, Inflammation by CHESS

Allergic rhinitis (AR) is a common chronic inflammatory condition. It has been previously indicated that oxidative stress may contribute to allergic inflammation, including AR. Although molecular hydrogen (H2), an antioxidative agent, has been effective in treatment of numerous oxidative stress-associated diseases, the effect of inhalation of a high concentration of H2 on AR remains unknown. In the current study, female …

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Hydrogen potentiates hypothermia and prevents hypotension and fever

In Animal studies, Inflammation by CHESS

Molecular hydrogen (H2) exerts anti-oxidative, anti-apoptotic, and anti-inflammatory effects. Here, the authors tested the hypothesis that H2 modulates cardiovascular, inflammatory, and thermoregulatory changes in systemic inflammation (SI) induced by lipopolysaccharide (LPS) at different doses (0.1 or 1.5 mg/kg, intravenously, to induce mild or severe SI) in male Wistar rats (250-300 g). LPS or saline was injected immediately before the beginning …

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Hydrogen-rich saline plays protective role in allergic inflammation

In Animal studies, Inflammation by CHESS

It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. The authors herein aim to verify …

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Hydrogen-rich water protects against inflammatory bowel disease

In Animal studies, Inflammation, Other studies by CHESS

The aim of this stuyd was to investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the …

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Preadministration of hydrogen-rich water protects against sepsis

In Animal studies, Inflammation, Liver by CHESS

Despite significant advances in antibiotic therapy and intensive care, sepsis remains the most common cause of death in intensive care units. The authors previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Here, the authors show that preadministration of H2-dissolved water (HW) suppresses lipopolysaccharide (LPS)-induced endotoxin shock in mice. Drinking HW for 3 days before LPS …

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Impact of molecular hydrogen on the innate immune activity and survival

In Animal studies, Inflammation by CHESS

Recently, molecular hydrogen has been reported to have a suppressive effect on inflammation in human and rodent models. The aim of this study was to evaluate the preventive effects of hydrogen-rich water (HRW) on zebrafish challenged by Aeromonas hydrophila. The authors have found an increased survival rate of bacteria-challenged zebrafish subjected to the HRW immersion treatment. Furthermore, they have revealed …

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Molecular hydrogen decelerates rheumatoid arthritis progression

In Animal studies, Inflammation by CHESS

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, the authors examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, the authors evaluated the effect of hydrogen on RA-FLSs development and the …

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Molecular hydrogen and hyperoxia improve survival rate and organ damage in inflammation

In Animal studies, Inflammation by CHESS

Multiple organ dysfunction syndrome (MODS) is a leading cause of mortality in critically ill patients. Hyperoxia treatment may be beneficial to critically ill patients. However, the clinical use of hyperoxia is hindered as it may exacerbate organ injury by increasing reactive oxygen species (ROS). Hydrogen gas (H2) exerts a therapeutic antioxidative effect by selectively reducing ROS. Combination therapy of H2 …

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Hydrogen improves lung function in sepsis

In Animal studies, Inflammation, Lung by CHESS

Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality. It has been reported that hydrogen-rich saline (HRS) has protective effects against sepsis-related lung injury. In this study, we hypothesized that the protective effect occurred by preserving the expression of AQP1 …

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Hydrogen-rich saline alleviates inflammation induced by severe burn

In Animal studies, Inflammation by CHESS

Severe burns with delayed resuscitation are associated with high morbidity which is attributed to ischemia-reperfusion injury. This study was undertaken to investigate the effect of hydrogen-rich saline known as a significant selective antioxidant on the inflammatory reaction induced by severe burns with delayed resuscitation. By establishing the model of severe burns with delayed resuscitation in rats, we recorded improvement on …