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Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

In Animal studies, Eye / Ear by CHESS

It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for …

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Hydrogen protects vestibular hair cells from free radicals

In Animal studies, Eye / Ear by CHESS

Hydrogen gas effectively protected against the morphological and functional vestibular hair cell damage by reactive oxygen species (ROS). ROS are generally produced by oxidative stress. In the inner ear, ROS levels increase as a result of noise trauma and ototoxic drugs and induce damage. It is thus important to control ROS levels in the inner ear. The protective effects of …

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Hydrogen protects auditory hair cells from ROS-induced damage

In Animal studies, Eye / Ear by CHESS

Reactive oxygen species (ROS) play a role in the degeneration of auditory hair cells because of aging, noise trauma, or ototoxic drugs. Hydrogenation is a fundamental reduction/de-oxidation reaction in living organisms. This study thus examined the potential of hydrogen to protect auditory hair cells from ROS-induced damage. To generate ROS, we applied antimycin A to explant cultures of auditory epithelia, …

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Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig

In Animal studies, Eye / Ear by CHESS

Molecular hydrogen (H(2)) is an efficient antioxidant that can selectively reduce hydroxyl radicals and inhibit oxidative stress-induced injuries. We investigated the protective effects and mechanism of hydrogen-rich saline in a glutamate-induced retinal injury model. Retinal excitotoxicity was induced in healthy guinea pigs by injecting glutamate into the vitreous cavity. After 30┬ámin, hydrogen-rich saline was injected into the vitreous cavity, the …

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Hydrogen rescues oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model

In Animal studies, Eye / Ear by CHESS

The main aim of this study was to o investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis. The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish …

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Neuroprotective effect of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury

In Animal studies, Eye / Ear by CHESS

Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Study results have indicated that molecular hydrogen (H(2)) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (*OH) and suppresses oxidative stress-induced injury in several organs. This study was conducted to explore the neuroprotective …