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Beneficial effect of hydrogen-rich saline on cerebral vasospasm after subarachnoid hemorrhage

In Animal studies, Cardiovascular by CHESS

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (¬∑OH) and ameliorate oxidative and inflammatory injuries to organs in many …

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Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts

In Animal studies, Cardiovascular by CHESS

Arterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties. We investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal hyperplasia. The inferior vena cava was excised, stored in cold Ringer solution for 2 h, and placed as an interposition graft …

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Hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia

In Animal studies, Cardiovascular by CHESS

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent studies have suggested that hydrogen (H(2)) may have an antioxidant effect by reducing hydroxyl radicals. In this study, we investigated the effects of …

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Hydrogen-rich saline prevents neointima formation after carotid balloon injury

In Animal studies, Cardiovascular by CHESS

Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in treating many diseases. Authors aimed to determine the mechanism by which hydrogen affects neointima formation. They assessed the influence of a hydrogen-rich saline solution (HRSS) by daily injection in rats. Rats were …

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Anti-inflammatory effect of hydrogen-rich saline in myocardial ischemia and reperfusion

In Animal studies, Cardiovascular by CHESS

The aim of this study was to study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. Myocardial I/R was established by occlusion of the left anterior descending (LAD) …

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Amelioration of rat cardiac ischemia injury with inhaled hydrogen

In Animal studies, Cardiovascular by CHESS

Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use. This study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Syngeneic heterotopic heart transplantation was performed in rats after 6 or 18 hours of cold ischemia in Celsior …

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The potential cardioprotective effects of hydrogen in irradiated mice

In Animal studies, Cardiovascular by CHESS

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury …

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Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury

In Animal studies, Cardiovascular by CHESS

Protective effect of hydrogen (H(2)) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlusion of the left anterior …

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Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

In Animal studies, Cardiovascular by CHESS

Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. Authors have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. Ohta, Hydrogen acts …

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Hydrogen gas reduces infarct size in the rat model of myocardial ischemia

In Animal studies, Cardiovascular by CHESS

Inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H(2) …