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Hydrogen gas inhalation attenuates endothelial glycocalyx damage

In Animal studies, Cardiovascular by CHESS

Hydrogen gas (H2) inhalation during hemorrhage stabilizes post-resuscitation hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation (HS/R) model. However, the underlying molecular mechanism of H2 in HS/R is unclear. Endothelial glycocalyx (EG) damage causes hemodynamic failure associated with HS/R. In this study, we tested the hypothesis that H2 alleviates oxidative stress by suppressing xanthine oxidoreductase (XOR) and/or …

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Hydrogen has a blood pressure-lowering effect

In Animal studies, Cardiovascular by CHESS

A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) …

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Hydrogen-rich water affects I3K/AKT signaling in myocardial injury

In Animal studies, Cardiovascular by CHESS

The effects of hydrogen-rich water on PI3K/AKT-mediated apoptosis were studied in rats subjected to myocardial ischemia-reperfusion injury (MIRI). Sixty rats were divided randomly into a hydrogen-rich water group and a control group. The hearts were removed and fixed in a Langendorff device. Hearts from the control group were perfused with K-R solution, and hearts from the hydrogen-rich water group was …

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Metabolomics of HRW use in myocardial injury

In Animal studies, Cardiovascular by CHESS

To investigate the effect of hydrogen-rich water on myocardial tissue metabolism in a myocardial ischemia-reperfusion injury (MIRI) rat model. Twelve rats were randomly divided into a hydrogen-rich water group and a control group of size 6 each. After the heart was removed, it was fixed in the Langendorff device, and the heart was perfused with 37 °C perfusion solution pre-balanced …

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Hydrogen-rich saline mitigates cardiac hypertrophy

In Animal studies, Cardiovascular by CHESS

The main aim of this study was to investigate if hydrogen-rich saline (HRS), which has been shown to have antioxidant and anti-inflammatory properties, could mitigate cardiac remodelling and reduce the incidence of atrial fibrillation (AF) in the rat model of cardiac hypertrophy. Pressure overload was induced in rats by abdominal aortic constriction (AAC). The animals were separated into four groups: …

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Hydrogen attenuates progression of chronic heart failure

In Animal studies, Cardiovascular by CHESS

Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. A total of 60 Sprague-Dawley (SD) rats were randomly divided into four groups: …

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Hydrogen inhalation improves outcomes in asphyxia induced-cardiac arrest

In Animal studies, Cardiovascular by CHESS

Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, the authors investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia …

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Hydrogen inhalation during EVLP improved donation after cardiac death

In Animal studies, Cardiovascular, Lung by CHESS

Ex vivo lung perfusion (EVLP) is a system that circulates normothermic perfusate into procured lungs, allowing for improved lung function and lung assessment. The authors investigated whether ventilation with hydrogen gas during EVLP improves the donation after cardiac death lung function and whether this effect persists after actual transplantation. Ten pigs were randomly divided into a control group (n = …

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Hydrogen prevents left ventricular hypertrophy in hypertension

In Animal studies, Cardiovascular by CHESS

Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H2) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of H2 on hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of H2 gas …

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Hydrogen gas reduces chronic hypertension

In Animal studies, Cardiovascular by CHESS

Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H2 ) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. The authors found that the …