View Post

Hydrogen-rich water protects against inflammatory bowel disease

In Animal studies, Inflammation, Other studies by CHESS

The aim of this stuyd was to investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the …

View Post

Effect of hydrogen-rich water on the CD34 expression in brain tissue of rats with brain injury

In Animal studies, Nervous system by CHESS

The main aim of this study was to observe the effect of hydrogen-rich water on the CD34 expression and angiogenesis in lesion boundary brain tissue of rats with traumatic brain injury (TBI). A total of 54 adult male Sprague-Dawley (SD) rats were divided into three groups by random number table: namely sham-operated group (sham group), trauma group (TBI group), and …

View Post

Hydrogen-rich saline for hepatectomy-induced cognitive dysfunction

In Animal studies, Liver, Nervous system by CHESS

This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24 each): control group (group C), hydrogen-rich saline group (group H), POCD group (group P), and POCD + hydrogen-rich saline group (group PH). …

View Post

Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury

In Animal studies, Gut by CHESS

This study aimed to investigate the protective effects of hydrogen rich water on the intestinal ischemia/reperfusion (I/R) injury in a rat intestinal intussusception (II) model. Ninety Sprague-Dawley rats were randomly assigned into three groups (n = 30 per group). In sham group, rats received laparotomy, and the intestine was exposed for 15 minutes without II. In I/R + saline group …

View Post

Preadministration of hydrogen-rich water protects against sepsis

In Animal studies, Inflammation, Liver by CHESS

Despite significant advances in antibiotic therapy and intensive care, sepsis remains the most common cause of death in intensive care units. The authors previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Here, the authors show that preadministration of H2-dissolved water (HW) suppresses lipopolysaccharide (LPS)-induced endotoxin shock in mice. Drinking HW for 3 days before LPS …

View Post

Hydrogen-rich water alleviates ethanol-induced fatty liver

In Animal studies, Liver by CHESS

The aim of this study was to investigate the effects of hydrogen-rich water (HRW) treatment on prevention of ethanol (EtOH)-induced early fatty liver in mice. In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control, EtOH, EtOH + silymarin, EtOH + HRW and EtOH + silymarin + …

View Post

Impact of molecular hydrogen on the innate immune activity and survival

In Animal studies, Inflammation by CHESS

Recently, molecular hydrogen has been reported to have a suppressive effect on inflammation in human and rodent models. The aim of this study was to evaluate the preventive effects of hydrogen-rich water (HRW) on zebrafish challenged by Aeromonas hydrophila. The authors have found an increased survival rate of bacteria-challenged zebrafish subjected to the HRW immersion treatment. Furthermore, they have revealed …

View Post

Hydrogen-rich water decreases anxiety-related behaviors and oxidative stress

In Animal studies, Nervous system by CHESS

In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. Natural reduced water and distilled water were administered to rats for 180 consecutive days, and …

View Post

Hydrogen-rich saline prevents bone loss in diabetes

In Animal studies, Metabolism by CHESS

As an antioxidant molecule, hydrogen has been received much more attention and reported to be used as the treatment strategy for various diseases. In this study, the authors hypothesize that systemic delivery of hydrogen saline water may improve the reservation of bone tissue in the tibias and femurs of osteoporotic rats caused by diabetes mellitus (DM), which is characterized by …