View Post

Hydrogen gas for moderate and severe neonatal hypoxia-ischemia in rat brain

In Animal studies, Nervous system by CHESS

Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model. In this study we tested H(2) in moderate (120 min hypoxia) and severe (150 min hypoxia) neonatal HI rat models. We hypothesized that H(2) would improve outcomes after neonatal HI by scavenging …

View Post

Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy

In Animal studies, Muscle by CHESS

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were divided into four groups: (1) the control …

View Post

Hydrogen protects mice from radiation induced thymic lymphoma

In Animal studies, Cancer by CHESS

Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found …

View Post

Hydrogen is neuroprotective against surgically induced brain injury

In Animal studies, Nervous system by CHESS

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague – Dawley rats (weight 300-350g) were divided into three groups to …

View Post

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

In Animal studies, Nervous system by CHESS

Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, authors investigated the efficacy of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse …