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Hydrogen-rich saline for allergic rhinitis

In Animal studies, Other studies by CHESS

Medical gas hydrogen (H2) has a special role in airway inflammation; however, the effect of H2 on allergic rhinitis (AR) remains unclear. This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13. An AR guinea pig model was established by nasal ovalbumin sensitisation. Eighteen guinea pigs …

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Protective effect of hydrogen on ovarian injury

In Animal studies, Other studies by CHESS

The present study aimed to investigate the effects of hydrogen-rich saline solution (HRSS) in a rat model of ovarian ischemia-reperfusion injury. Thirty-six female Wistar-albino rats were grouped randomly, into six groups of six rats. The groups were classified as: sham (S), hydrogen (H), torsion (T), torsion/detorsion (TD), hydrogen-torsion (HT), and hydrogen-torsion/detorsion (HTD). Bilateral adnexal torsion was performed for 3h in …

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Hydrogen-rich saline attenuates testicular injury

In Animal studies, Other studies by CHESS

To study how hydrogen-rich saline (HS) promotes the recovery of testicular biological function in a hemi-sectioned spinal cord injury (hSCI) rat model, a right hemisection was performed at the T11-T12 of the spinal cord in Wistar rats. Animals were divided into four groups: normal group; vehicle group: sham-operated rats administered saline; hSCI group: subjected to hSCI and administered saline; HRST …

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Hydrogen for chronic graft-versus-host disease

In Animal studies, Other studies by CHESS

The incidence of chronic graft-versus-host disease (cGVHD) is rising recent years, which has been the leading cause of non-transplantation mortality post allogenetic hematopoietic stem cell transplantation (HSCT). Imbalance of inflammatory cytokines and fibrosis plays critical roles in the pathogenesis of cGVHD. Recent studies showed that molecular hydrogen has anti-inflammatory, antioxidant, anti-fibrosis effects. Therefore, the authors hypothesized that molecular hydrogen may …

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Hydrogen-rich saline prevents bone loss in diabetes

In Animal studies, Metabolism, Other studies by CHESS

As an antioxidant molecule, hydrogen has been received much more attention and reported to be used as the treatment strategy for various diseases. In this study, the athors hypothesize that systemic delivery of hydrogen saline water may improve the reservation of bone tissue in the tibias and femurs of osteoporoticrats caused by diabetes mellitus (DM), which is characterized by increased …

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Effect of hydrogen on postoperative intra-abdominal adhesion bands formation

In Animal studies, Other studies by CHESS

Postsurgical peritoneal adhesions (PPAs) are pathologic fibrous bands within the peritoneal cavity. The aim of this study was to investigate the protective effect of hydrogen-rich saline (HRS) on PPAs formation in mice. Adhesions were induced in mice using the cecum rubbing model. The mice were allocated into 4 groups: control sham group without cecum rubbing; PPA group with saline applied …

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Hydrogen-rich water ameliorates total body irradiation-induced hematopoietic stem cell injury

In Animal studies, In vitro studies, Other studies by CHESS

The authors examined whether consumption of hydrogen-rich water (HW) could ameliorate hematopoietic stem cell (HSC) injury in mice with total body irradiation (TBI). The results indicated that HW alleviated TBI-induced HSC injury with respect to cell number alteration and to the self-renewal and differentiation of HSCs. HW specifically decreased hydroxyl radical (∙OH) levels in the c-kit+ cells of 4 Gy irradiated …

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Preventive effects of drinking hydrogen-rich water on gingival oxidative stress and alveolar bone resorption

In Animal studies, Other studies by CHESS

Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. The authors examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Male Fischer 344 …

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Hydrogen-rich water protects against inflammatory bowel disease

In Animal studies, Inflammation, Other studies by CHESS

The aim of this stuyd was to investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the …