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Hydrogen-rich saline prevents bone loss in diabetes

In Animal studies, Metabolism by CHESS

As an antioxidant molecule, hydrogen has been received much more attention and reported to be used as the treatment strategy for various diseases. In this study, the authors hypothesize that systemic delivery of hydrogen saline water may improve the reservation of bone tissue in the tibias and femurs of osteoporotic rats caused by diabetes mellitus (DM), which is characterized by …

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Hydrogen exerts metabolic effects similar to those of insulin in type 2 diabetic mice

In Animal studies, Metabolism by CHESS

Hydrogen (H(2)) acts as a therapeutic antioxidant. However, there are few reports on H(2) function in other capacities in diabetes mellitus (DM). Therefore, in this study, authors investigated the role of H(2) in glucose transport by studying cultured mouse C2C12 cells and human hepatoma Hep-G2 cells in vitro, in addition to three types of diabetic mice [Streptozotocin (STZ)-induced type 1 …

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Therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus

In Animal studies, Metabolism by CHESS

Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection of a …

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Effects of hydrogen-rich water on abnormalities in a metabolic syndrome rat model.

In Animal studies, Metabolism by CHESS

Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic syndrome rat model, …

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Drinking hydrogen water reduced hepatic oxidative stress and alleviated fatty liver in mice

In Animal studies, Metabolism by CHESS

Recent extensive studies have revealed that molecular hydrogen (H(2)) has great potential for improving oxidative stress-related diseases by inhaling H(2) gas, injecting saline with dissolved H(2), or drinking water with dissolved H(2) (H(2)-water); however, little is known about the dynamic movement of H(2) in a body. First, authors show that hepatic glycogen accumulates H(2) after oral administration of H(2)-water, explaining …