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Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease

In Animal studies, Lung by CHESS

Chronic obstructive pulmonary disease induced by tobacco smoke has been regarded as a great health problem worldwide. The purpose of this study is to evaluate the protective effect of hydrogen-rich saline, a novel antioxidant, on chronic obstructive pulmonary disease and explore the underlying mechanism. Sprague-Dawley rats were made chronic obstructive pulmonary disease models via tobacco smoke exposure for 12 weeks …

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Hydrogen-rich water prevents cigarette smoke-induced pulmonary emphysema

In Animal studies, Lung by CHESS

Chronic obstructive pulmonary disease (COPD) is predominantly a cigarette smoke (CS)-triggered disease with features of chronic systemic inflammation. Oxidants derived from CS can induce DNA damage and stress-induced premature cellular senescence in the respiratory system, which play significant roles in COPD. Therefore, antioxidants should provide benefits for the treatment of COPD; however, their therapeutic potential remains limited owing to the …

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Immersing lungs in hydrogen-rich saline attenuates ischaemia–reperfusion injury

In Animal studies, Lung by CHESS

Anti-oxidant effects of hydrogen have been reported in studies examining ischaemia–reperfusion injury (IRI). In this study, the authors evaluated the therapeutic efficacy of immersing lungs in hydrogen-rich saline on lung IRI. Lewis rats were divided into three groups: (i) sham, (ii) normal saline and (iii) hydrogen-rich saline. In the first experiment, the left thoracic cavity was filled with either normal …

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Lung inflation with hydrogen reduced lung injury

In Animal studies, Lung by CHESS

Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)’s anti-inflammatory effect or hydrogen (H2)’s anti-oxidant effect. In this study, the effects of lung inflation with CO, H2, or both during the cold ischemia phase on graft function were observed. Rat donor lungs, inflated with 40% oxygen (control group), 500ppm CO (CO group), 3% H2 (H2 group) or 500ppm …

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Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury

In Animal studies, Lung by CHESS

Seawater instillation-induced acute lung injury involves oxidative stress and apoptosis. Although hydrogen gas inhalation is reportedly protective in multiple types of lung injury, the effect of hydrogen gas inhalation on seawater instillation-induced acute lung injury remains unknown. This study investigated the effect of hydrogen gas on seawater instillation-induced acute lung injury and explored the mechanisms involved. Rabbits were randomly assigned …

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Hydrogen-rich water ameliorates bronchopulmonary dysplasia

In Animal studies, Lung by CHESS

Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. The authors made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at …

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Hydrogen improves lung function in sepsis

In Animal studies, Inflammation, Lung by CHESS

Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality. It has been reported that hydrogen-rich saline (HRS) has protective effects against sepsis-related lung injury. In this study, we hypothesized that the protective effect occurred by preserving the expression of AQP1 …

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Molecular hydrogen with NO provide enhanced therapeutic efficacy in acute lung injury

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Inhaled nitric oxide (NO) has been reported to ameliorate ALI. However, reactive nitrogen species produced by NO can cause lung injury. Because hydrogen gas (H2) is reported to eliminate peroxynitrite, it is expected to reduce the adverse effects of NO. Moreover, we have …

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Hydrogen-rich saline ameliorates acute lung injury

In Animal studies, Lung by CHESS

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. The experiments exhibited that gas exchange dysfunction and …

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Effects of three hydrogen-rich liquids on lung injury-induced hemorrhagic shock

In Animal studies, Lung by CHESS

Hydrogen-rich saline provides a high concentration of hydrogen, which selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. Authors investigated the protective effects and mechanisms of three different hydrogen-rich liquid resuscitation preparations on lung injury-induced uncontrolled-hemorrhagic shock (UHS) in rats. A UHS rat model was prepared using the method of Capone et al. of arterial bleeding …