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Impact of molecular hydrogen on the innate immune activity and survival

In Animal studies, Inflammation by CHESS

Recently, molecular hydrogen has been reported to have a suppressive effect on inflammation in human and rodent models. The aim of this study was to evaluate the preventive effects of hydrogen-rich water (HRW) on zebrafish challenged by Aeromonas hydrophila. The authors have found an increased survival rate of bacteria-challenged zebrafish subjected to the HRW immersion treatment. Furthermore, they have revealed …

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Molecular hydrogen decelerates rheumatoid arthritis progression

In Animal studies, Inflammation by CHESS

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, the authors examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, the authors evaluated the effect of hydrogen on RA-FLSs development and the …

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Molecular hydrogen and hyperoxia improve survival rate and organ damage in inflammation

In Animal studies, Inflammation by CHESS

Multiple organ dysfunction syndrome (MODS) is a leading cause of mortality in critically ill patients. Hyperoxia treatment may be beneficial to critically ill patients. However, the clinical use of hyperoxia is hindered as it may exacerbate organ injury by increasing reactive oxygen species (ROS). Hydrogen gas (H2) exerts a therapeutic antioxidative effect by selectively reducing ROS. Combination therapy of H2 …

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Hydrogen improves lung function in sepsis

In Animal studies, Inflammation, Lung by CHESS

Aquaporin 1(AQP1) and AQP5 have an important role in eliminating extravascular lung water, an increase of which contributes to lung injury in patients with sepsis and its consequent mortality. It has been reported that hydrogen-rich saline (HRS) has protective effects against sepsis-related lung injury. In this study, we hypothesized that the protective effect occurred by preserving the expression of AQP1 …

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Hydrogen-rich saline alleviates inflammation induced by severe burn

In Animal studies, Inflammation by CHESS

Severe burns with delayed resuscitation are associated with high morbidity which is attributed to ischemia-reperfusion injury. This study was undertaken to investigate the effect of hydrogen-rich saline known as a significant selective antioxidant on the inflammatory reaction induced by severe burns with delayed resuscitation. By establishing the model of severe burns with delayed resuscitation in rats, we recorded improvement on …

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Hydrogen-rich saline ameliorates lung injury and puncture-induced sepsis

In Animal studies, Inflammation, Lung by CHESS

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Our experiments exhibited that gas …

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Effects of hydrogen treatment on polymicrobial sepsis

In Animal studies, Inflammation by CHESS

Hydrogen has been reported to selectively reduce hydroxyl radicals and peroxynitrite anion in many pathologic processes. This study aimed to test the hypothesis that hydrogen-rich saline (HRS) may ameliorate organ dysfunction in a rat model of polymicrobial sepsis. Sepsis was induced in male Sprague-Dawley rats by cecal ligation and puncture (CLP). Twenty-four rats were equally assigned to Sham group, CLP …

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Hydrogen-rich saline in rats submitted to sepsis

In Animal studies, Inflammation by CHESS

Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction. The present study was performed to investigate the effects of hydrogen-rich saline (HRS) on oxidative stress in the brain, cognitive dysfunction, and mortality in a rat model of sepsis. A rat model of sepsis was induced by cecal ligation and puncture. Physiologic saline or HRS …

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Anti-inflammation effects of hydrogen saline

In Animal studies, Inflammation by CHESS

Oxidative stress is thought to play an important role in the pathogenesis of inflammation. Recent studies have found that hydrogen gas has the effect of eliminating free radicals. Whether hydrogen saline (more convenient to be used than hydrogen gas) has the anti-inflammation effect or not is still unknown. Carrageenan-induced paw oedema and LPS-activated macrophages are studied in this article. Injection …

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Anti-inflammatory properties of molecular hydrogen in parasite-induced liver disease

In Animal studies, Inflammation by CHESS

Molecular hydrogen reacts with the hydroxyl radical, a highly cytotoxic species produced in inflamed tissues. It has been suggested therefore to use gaseous hydrogen in a new anti-inflammatory strategy. Authors tested this idea, with the aid of the equipment and skills of COMEX SA in Marseille, a group who experiments with oxygen-hydrogen breathing mixtures for professional deep-sea diving. The model …