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Hydrogen gas protects against intestinal injury

In Animal studies, Gut by CHESS

The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive master switch that regulates the expression of antioxidant and protective enzymes. This study investigated the effects of 2% H2 on intestinal …

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Hydrogen-rich water protects against inflammatory bowel disease

In Animal studies, Gut by CHESS

The aim of this study was to investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the …

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Protective effects of hydrogen rich water on intestinal intussusception

In Animal studies, Gut by CHESS

This study aimed to investigate the protective effects of hydrogen rich water on the intestinal ischemia/reperfusion (I/R) injury in a rat intestinal intussusception (II) model. Ninety Sprague-Dawley rats were randomly assigned into three groups (n = 30 per group). In sham group, rats received laparotomy, and the intestine was exposed for 15 minutes without II. In I/R + saline group …

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Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis and bacterial translocation in sepsis.

In Animal studies, Gut by CHESS

Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management is an important therapeutic strategy. In this study, the authors focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine model of sepsis. …

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Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury

In Animal studies, Gut by CHESS

This study aimed to investigate the protective effects of hydrogen rich water on the intestinal ischemia/reperfusion (I/R) injury in a rat intestinal intussusception (II) model. Ninety Sprague-Dawley rats were randomly assigned into three groups (n = 30 per group). In sham group, rats received laparotomy, and the intestine was exposed for 15 minutes without II. In I/R + saline group …

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Inhaled hydrogen ameliorates bowel dysfunction

In Animal studies, Gut by CHESS

Gastrointestinal dysmotility frequently occurs during sepsis and multiple organ failure, remaining a major cause of morbidity and mortality in critically ill patients. Previous studies have shown that hydrogen, a new therapeutic gas, can improve various organ damage associated with sepsis. In this study, the authors investigated the protective efficacy of inhaled hydrogen against lipopolysaccharide (LPS)-induced ileus. Sepsis was induced in …

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Hydrogen-rich physiologic solution protects against postoperative ileus

In Animal studies, Gut by CHESS

Postoperative ileus, a transient impairment of bowel motility initiated by intestinal inflammation, is common after an abdominal operation and leads to increased hospital stays and costs. Hydrogen has potent anti-inflammatory and antioxidant properties and potential therapeutic value. Solubilized hydrogen may be a portable and practical means of administering therapeutic hydrogen gas. The authors hypothesized that intraperitoneal administration of hydrogen-rich saline …

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Hydrogen water accelerates oral wound healing

In Animal studies, Gut by CHESS

The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory …

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Injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury

In Animal studies, Gut by CHESS

Luminal preservation of the intestine is an attractive method to locally mitigate preservation injury and ischemic-reperfusion injury in small bowel transplantation (SBT) because this method has a potential to maintain the intestinal graft integrity. Hydrogen is noted as an antioxidant material by reducing hydroxyl radicals. Authors hypothesized that hydrogen-containing solution can be an optimum material for luminal preservation method in …

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Hydrogen solution protects against intestinal injury

In Animal studies, Gut by CHESS

Intestinal tissue got largely decreased blood supply in uncontrolled hemorrhagic shock, because of limited blood mainly supporting brain, heart, kidney etc. This makes intestine as the primary injury target after uncontrolled hemorrhagic shock. However, limited studies focus on how to protect intestine against hemorrhagic shock. Ringer’s solution, pentoxifylline and hypertonic saline are widely used to resuscitate in haemorrhagic shock and …