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Inhaled hydrogen promotes survival of retinal cells

In Animal studies, Eye / Ear by CHESS

Retinal ischemia/reperfusion (I/R) injury plays a crucial role in the pathophysiology of various ocular diseases. Intraperitoneal injection or ocular instillation with hydrogen (H2)-rich saline was recently shown to be neuroprotective in the retina due to its anti-oxidative and anti-inflammatory effects. This study aims to explore whether postconditioning with inhaled H2 can protect retinal ganglion cells (RGCs) in a rat model …

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Hydrogen is ineffective in O2-induced retinopathy

In Animal studies, Eye / Ear by CHESS

Hydrogen-rich saline (HRS) is a novel protection against various oxidative disorders and almost all types of inflammation. Moreover, its toxicity and side effects are rarely reported. The authors sought to clarify the protective effect of HRS against the oxygen-induced retinopathy (OIR) in C57BL/6 J model. The OIR in the HRS treated mice and the untreated controls were systematically compared. The …

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Protective effects of hydrogen against photoreceptor degeneration

In Animal studies, Eye / Ear by CHESS

The N-methyl-N-nitrosourea (MNU)-treated rat is typically used as an animal model of chemically-induced retinitis pigmentosa (RP). Reactive oxygen species (ROS) have been recognized as the crucial contributor to the retinal photoreceptor apoptosis seen in MNU-treated rats. In the present study, authors explored the therapeutic effects of hydrogen-rich saline (HRS), a selective ROS scavenger, on MNU-induced photoreceptor degeneration. Intraperitoneal (IP) administration …

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Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss

In Animal studies, Eye / Ear by CHESS

Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. The authors tested this hypothesis in guinea pigs with 0.5%, 1.0% and 1.5% …

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Hydrogen-rich saline has a neuroprotective effect on retinal ischemia-reperfusion injury

In Animal studies, Eye / Ear by CHESS

Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia-reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen-rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP-1 activation. RIR was induced by transient elevation of intraocular pressure in rats. …

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Hydrogen-rich saline provides protection and treatment against light-induced retinal damage

In Animal studies, Eye / Ear by CHESS

Oxidative reactions are thought to be a major cause of light-induced retinal degeneration. This study was designed to investigate the effects of hydrogen-rich saline (HRS) on the prevention and treatment of light-induced retinal injury in rats. Male Sprague-Dawley rats were divided randomly into three groups: light damage, HRS prevention (5 ml/kg, 30 min before intensive light exposure), and HRS treatment (5 ml/kg per …

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Hydrogen alleviates noise-induced hearing loss

In Animal studies, Eye / Ear by CHESS

This study examined the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and NO TREATMENT (normal control) groups. The HS+NOISE, NS+NOISE, and NOISE ALONE groups were exposed to intensive noise (4 h …

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Hydrogen prevents selenite-induced cataract

In Animal studies, Eye / Ear by CHESS

The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats. Sprague-Dawley rat pups were divided into the following groups: control (Group A), selenite induced (Group B), and selenite plus hydrogen saline treated (Group C). Rat pups in Groups B and C received a single …

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Protective effect of saturated hydrogen saline against retinal damage

In Animal studies, Eye / Ear by CHESS

This study explored the effect of saturated hydrogen saline on blue light-induced retinal damage in rats. The retinal damage of rats was induced by blue light exposure for 6 hours and examined 8 hours, 16 hours and 24 hours after the exposure. One hundred female Sprague-Dawley rats were randomly divided into four groups. Group 1 included 30 rats received light …

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Hydrogen saline treatment attenuates hyperoxia-induced retinopathy in mouse

In Animal studies, Eye / Ear by CHESS

Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal neovascularization. Previous reports have indicated that hydrogen has a therapeutic, antioxidant activity by selectively reducing hydroxyl radicals. This study examined the therapeutic effect of hydrogen saline on …