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Hydrogen inhalation for neurological outcomes and survival in a cardiac arrest

In Animal studies, Cardiovascular by CHESS

Postcardiac arrest syndrome is the consequence of whole-body ischemia-reperfusion events that lead to multiple organ failure and eventually to death. Recent animal studies demonstrated that inhalation of hydrogen greatly mitigates postresuscitation myocardial dysfunction and brain injury. However, the influence of underlying heart disease on the efficacy of hydrogen is still unknown. In the present study, the authors investigated the effects …

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Hydrogen-rich saline attenuates brain injury induced by cardiopulmonary bypass

In Animal studies, Cardiovascular, Nervous system by CHESS

Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway. A rat CPB model and an in vitro cell hypoxia model were established. After HRS …

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Hydrogen attenuates brain injury after cardiac arrest

In Animal studies, Cardiovascular, Nervous system by CHESS

Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest. The rats were randomly divided …

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Gaseous hydrogen improves myocardial dysfunction

In Animal studies, Cardiovascular by CHESS

Immediate inhalation of hydrogen (H2) has been demonstrated to improve post-resuscitation (PR) myocardial dysfunction. In this study, the authors investigated the effects of delayed treatments with H2 on myocardial dysfunction in a porcine model of cardiac arrest (CA). Twenty male pigs weighing 39 ± 2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 10 min. All the …

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Hydrogen inhalation improves survival in hemorrhagic shock

In Animal studies, Cardiovascular by CHESS

Hemorrhagic shock is a life-threatening condition. In addition to conventional treatments such as hemostasis and fluid resuscitation, further investigations are warranted to develop more effective treatments. The study investigated the effectiveness of hydrogen (H2) gas inhalation in a fixed-pressure model of hemorrhagic shock in rats. Hemorrhagic shock is induced by withdrawing blood from the left carotid artery until the mean …

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Hydrogen inhalation improves cardiac function and neurological outcomes in cardiac arrest

In Animal studies, Cardiovascular by CHESS

Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, the authors investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac arrest. Cardiopulmonary resuscitation was initiated after 5 …

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Hydrogen gas for post-cardiac arrest syndrome

In Cardiovascular, Human studies by CHESS

Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target …

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Hydrogen-rich saline attenuates heart dysfunction by restoring fatty acid oxidation

In Animal studies, Cardiovascular by CHESS

Sepsis is common in intensive care units (ICU) and is associated with high mortality. Cardiac dysfunction complicating sepsis is one of the most important causes of this mortality. This dysfunction is due to myocardial inflammation and reduced production of energy by the heart. A number of studies have shown that hydrogen-rich saline (HRS) has a beneficial effect on sepsis. Therefore, …

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Cardioprotective effect of hydrogen-rich saline on myocardial infarction

In Animal studies, Cardiovascular by CHESS

Infusion with hydrogen gas-saturated saline has recently been reported to exert antioxidant and anti-inflammatory activity that may protect against organ damage induced by oxidative stress. Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction (MI), the aim of this study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats. An …

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Effects of hydrogen-rich saline on Akt/GSK3β signaling pathways and cardiac function

In Animal studies, Cardiovascular by CHESS

This study explored the effects of hydrogen-rich saline on Akt/GSK3β signaling pathways and cardiac function during myocardial ischemia-reperfusion (I/R) in rats. A total of 150 healthy male Sprague-Dawley rats were selected and divided randomly into 5 groups of normal control (I), sham operation (II), myocardial ischemia-reperfusion (III), hydrogen-rich saline (IV) and normal saline group (V) (n = 30 each). Group …