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Hydrogen inhalation protects against ototoxicity

In Animal studies, Eye / Ear by CHESS

Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induced by intravenous cisplatin. …

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Hydrogen can alleviate post-cardiac arrest myocardium injury

In Animal studies, Cardiovascular by CHESS

This study investigated the effects of hydrogen (H2) on myocardium injury post-cardiac arrest (CA) in rabbits. Sixty New Zealand rabbits were randomly divided into H2 treatment group (n = 30) and control group (n = 30) by random number table. The rabbit CA model was established by means of electrical stimulation of external membrane, both groups were mechanically ventilated. Cardiopulmonary …

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Protective effect of hydrogen gas inhalation on muscular damage

In Animal studies, Muscle by CHESS

Ischemia-reperfusion injury is one of the leading causes of tissue damage and dysfunction, in particular, free tissue transfer, traumatically amputated extremity, and prolonged tourniquet application during extremity surgery. In this study, the authors investigated the therapeutic effects of hydrogen gas on skeletal muscle ischemia-reperfusion injury. The authors compared the concentration of hydrogen in a muscle on intraperitoneal administration of hydrogen-rich …

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Hydrogen inhalation for neurological outcomes and survival in a cardiac arrest

In Animal studies, Cardiovascular by CHESS

Postcardiac arrest syndrome is the consequence of whole-body ischemia-reperfusion events that lead to multiple organ failure and eventually to death. Recent animal studies demonstrated that inhalation of hydrogen greatly mitigates postresuscitation myocardial dysfunction and brain injury. However, the influence of underlying heart disease on the efficacy of hydrogen is still unknown. In the present study, the authors investigated the effects …

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Hydrogen inhalation promotes survival after retinal injury

In Animal studies, Eye / Ear by CHESS

Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. A previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the right eyes of rats …

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Hydrogen-rich saline attenuates brain injury induced by cardiopulmonary bypass

In Animal studies, Cardiovascular, Nervous system by CHESS

Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway. A rat CPB model and an in vitro cell hypoxia model were established. After HRS …

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Hydrogen-rich saline for allergic rhinitis

In Animal studies, Other studies by CHESS

Medical gas hydrogen (H2) has a special role in airway inflammation; however, the effect of H2 on allergic rhinitis (AR) remains unclear. This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13. An AR guinea pig model was established by nasal ovalbumin sensitisation. Eighteen guinea pigs …

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Hydrogen-rich saline plays protective role in allergic inflammation

In Animal studies, Inflammation by CHESS

It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. The authors herein aim to verify …

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Hydrogen attenuates brain injury after cardiac arrest

In Animal studies, Cardiovascular, Nervous system by CHESS

Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest. The rats were randomly divided …

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Hydrogen-rich water protects against inflammatory bowel disease

In Animal studies, Gut by CHESS

The aim of this study was to investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the …