View Post

Effect of hydrogen-rich saline on allergic rhinitis

In Animal studies, Eye / Ear by CHESS

This study explored the effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells in a guinea pig model of allergic rhinitis (AR) and investigate the underling anti-inflammatory mechanism. Using random number table, eighteen guinea pigs were divided into three groups (control group/AR group/HRS group, n=6 of each group). AR guinea pig model was built with ovalbumin and aluminum. …

View Post

Hydrogen-rich saline alleviates kidney fibrosis

In Animal studies, Kidney by CHESS

Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno-protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI. Adult male C57 mice were randomly allocated into three groups: Sham, IR, IR+HRS. Renal …

View Post

Injection of hydrogen-rich saline against retinal degeneration

In Animal studies, Eye / Ear by CHESS

Retinitis pigmentosa (RP) comprises a heterogeneous group of inherited retinal diseases leading to blindness. The present study explored the protective effects of hydrogen rich saline (HRS) against the photoreceptor degeneration in the N-Methyl-N-nitrosourea (MNU) administrated rat, a pharmacologically induced RP model. The therapeutic effects of intraperitoneal (IP) and intravitreous (IV) injections of HRS on regional retina was quantified via topographic …

View Post

Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease

In Animal studies, Lung by CHESS

Chronic obstructive pulmonary disease induced by tobacco smoke has been regarded as a great health problem worldwide. The purpose of this study is to evaluate the protective effect of hydrogen-rich saline, a novel antioxidant, on chronic obstructive pulmonary disease and explore the underlying mechanism. Sprague-Dawley rats were made chronic obstructive pulmonary disease models via tobacco smoke exposure for 12 weeks …

View Post

Hydrogen for chronic graft-versus-host disease

In Animal studies, Other studies by CHESS

The incidence of chronic graft-versus-host disease (cGVHD) is rising recent years, which has been the leading cause of non-transplantation mortality post allogenetic hematopoietic stem cell transplantation (HSCT). Imbalance of inflammatory cytokines and fibrosis plays critical roles in the pathogenesis of cGVHD. Recent studies showed that molecular hydrogen has anti-inflammatory, antioxidant, anti-fibrosis effects. Therefore, the authors hypothesized that molecular hydrogen may …

View Post

Hydrogen-rich saline prevents bone loss in diabetes

In Animal studies, Metabolism, Other studies by CHESS

As an antioxidant molecule, hydrogen has been received much more attention and reported to be used as the treatment strategy for various diseases. In this study, the athors hypothesize that systemic delivery of hydrogen saline water may improve the reservation of bone tissue in the tibias and femurs of osteoporoticrats caused by diabetes mellitus (DM), which is characterized by increased …

View Post

Amelioration of retinitis pigmentosa by hydrogen-rich saline

In Animal studies, Eye / Ear by CHESS

The main aim of this study was to investigate the effects of hydrogen-rich saline (HRS) on microglia activation and Sirtuin type 1 (Sirt1) in rats with N-methyl-N-nitrosourea (MNU)-induced retinitis pigmentosa (RP). Rats were divided into norm (N) group, model (M) group and HRS (H) group. Rats in M and H groups were given saline and HRS respectively prior to and …

View Post

Effect of hydrogen on postoperative intra-abdominal adhesion bands formation

In Animal studies, Other studies by CHESS

Postsurgical peritoneal adhesions (PPAs) are pathologic fibrous bands within the peritoneal cavity. The aim of this study was to investigate the protective effect of hydrogen-rich saline (HRS) on PPAs formation in mice. Adhesions were induced in mice using the cecum rubbing model. The mice were allocated into 4 groups: control sham group without cecum rubbing; PPA group with saline applied …

View Post

Hydrogen-rich saline ameliorates hepatic ischemia-reperfusion injury

In Animal studies, Liver by CHESS

The aim of this study was to evaluate the effect of hydrogen-rich saline (HS) on hepatic ischemia-reperfusion (I/R) injury. Forty rats were randomly allocated into five groups: one sham group (control group), one group treated with 20 min of ischemia and normal saline (NS; I/R1 + NS group), one group treated with 20 min of ischemia and HS (I/R1 + HS group), one group treated with …

View Post

Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis and bacterial translocation in sepsis.

In Animal studies, Gut by CHESS

Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management is an important therapeutic strategy. In this study, the authors focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine model of sepsis. …