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Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life

In Human studies, Nervous system by CHESS

Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several …

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Prevention of ischemia-induced hearing loss by hydrogen-rich saline

In Animal studies, Eye / Ear by CHESS

Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5min. Five milliliters of hydrogen-rich saline was then intravenously administered immediately after the insult. Saline without hydrogen was used as a control. Effects …

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Molecular hydrogen positively affected post-exercise recovery

In Exercise, Human studies by CHESS

Molecular hydrogen (H2) recently appeared as a novel and safe ergogenic agent that might have beneficial effects in athletes. However, no information is available concerning the impact of H2 on post-exercise recovery indices. The purpose of this study was to determine the effects of pre-exercise H2 administration on post-exercise heart rate and blood lactate responses in judo athletes. Five athletes …

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Neuroprotective potential of molecular hydrogen against perinatal brain injury

In Animal studies, Nervous system by CHESS

Exposure to inflammation in utero is related to perinatal brain injury, which is itself associated with high rates of long-term morbidity and mortality in children. Novel therapeutic interventions during the perinatal period are required to prevent inflammation, but its pathogenesis is incompletely understood. Activated microglia are known to play a central role in brain injury by producing a variety of …

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Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation

In In vitro studies by CHESS

The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation that can be blocked by some mitochondria-targeted antioxidants. Known …

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Immersing lungs in hydrogen-rich saline attenuates ischaemia–reperfusion injury

In Animal studies, Lung by CHESS

Anti-oxidant effects of hydrogen have been reported in studies examining ischaemia–reperfusion injury (IRI). In this study, the authors evaluated the therapeutic efficacy of immersing lungs in hydrogen-rich saline on lung IRI. Lewis rats were divided into three groups: (i) sham, (ii) normal saline and (iii) hydrogen-rich saline. In the first experiment, the left thoracic cavity was filled with either normal …

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Molecular hydrogen decelerates rheumatoid arthritis progression

In Animal studies, Inflammation by CHESS

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, the authors examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, the authors evaluated the effect of hydrogen on RA-FLSs development and the …

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Protective effects of hydrogen against low-dose long-term radiation

In Animal studies, Other studies by CHESS

Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, the authors investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of …

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Clinical application of molecular hydrogen in hemodialysis

In Review papers by CHESS

Increased oxidative stress and pro-inflammatory conditions, commonly present in chronic dialysis patients, are thought to be enhanced during hemodialysis (HD) and to be associated with the excess morbidity and mortality seen in these patients. The hydrogen molecule (H2) has a unique biological capacity to act as an antioxidative and anti-inflammatory substance. In light of accumulating evidence from animal studies showing …

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Hydrogen-rich medium ameliorates lipopolysaccharide-induced barrier dysfunction

In In vitro studies by CHESS

Gastrointestinal barrier dysfunction is associated with the severity and prognosis of sepsis. Hydrogen gas (H2) can ameliorate multiple organ damage in septic animals. Ras homolog gene family member A (RhoA) and mammalian diaphanous-related formin 1 (mDia1) are important to regulate tight junction (TJ) and adherens junction (AJ), both of which determine the integrity of the intestinal barrier. This study was …