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Melanin as a possible source of bioactive molecular hydrogen

In Review papers by CHESS

Molecular hydrogen (dihydrogen; H2) has traditionally been described as a biologically inactive gas, with low capacity to react with most biomolecules. However, in the past two decades hydrogen emerged as a potent therapeutic agent, with antioxidant, anti-inflammatory and anti-apoptotic effects demonstrated in a plethora of animal disease models and human studies. Prominent effects of supplemental H2 in clinical environment are …

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Molecular hydrogen therapy ameliorates organ damage induced by sepsis

In Review papers by CHESS

Since it was proposed in 2007, molecular hydrogen therapy has been widely concerned and researched. Many animal experiments were carried out in a variety of disease fields, such as cerebral infarction, ischemia reperfusion injury, Parkinson syndrome, type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, stress ulcer, acute sports injuries, mitochondrial and inflammatory disease, …

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Hydrogen therapy: from mechanism to cerebral diseases

In Review papers by CHESS

The medicinal value of hydrogen (H2) was ignored prior to research illustrating that inhalation of 2% H2 can significantly decrease the damage of cerebral ischemia/reperfusion caused by oxidative stress via selective elimination of hydroxyl freebase (OH) and peroxynitrite anion (ONOO-). Subsequently, there have been numerous experiments on H2. Most research and trials involving the mechanisms underlying H2 therapy show the …

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Molecular hydrogen alleviates cellular senescence in human endothelial cells

In In vitro studies by CHESS

Substantial evidence indicates that molecular hydrogen (H2) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects. Thus, hydrogen-rich water may prove to be an effective anti-aging drink. This study examined the effects of H2 on endothelial senescence and clarified the mechanisms involved. Hydrogen-rich medium was produced by a high-purity hydrogen gas generator. Human umbilical vein endothelial cells (HUVECs) …