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Application of molecular hydrogen as a medical treatment in clinical medicine

In Review papers by CHESS

In recent years, it has become evident that molecular hydrogen is a particularly effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogen’s effectiveness is …

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Hydrogen protects against cell death and senescence induced by oxidative damage

In In vitro studies by CHESS

Hydrogen has potential for preventive and therapeutic applications as an antioxidant. However, micro- and macroparticles of hydrogen in water disappear easily over time. In order to eliminate reactive oxygen species (ROS) related with the aging process, the authors used functional water containing nanoparticle hydrogen. Nanoparticle hydrogen does not disappear easily and collapses under water for long periods of time. The …

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Hydrogen-rich physiologic solution protects against postoperative ileus

In Animal studies, Gut by CHESS

Postoperative ileus, a transient impairment of bowel motility initiated by intestinal inflammation, is common after an abdominal operation and leads to increased hospital stays and costs. Hydrogen has potent anti-inflammatory and antioxidant properties and potential therapeutic value. Solubilized hydrogen may be a portable and practical means of administering therapeutic hydrogen gas. The authors hypothesized that intraperitoneal administration of hydrogen-rich saline …

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Protective effects of hydrogen gas on cell death in Schwann cells

In In vitro studies by CHESS

This study aimed to investigate the protective effects and underlying molecular mechanisms of hydrogen (H2) on high glucose-induced poly (ADP-ribose) polymerase-1 (PARP-1) dependent cell death (PARthanatos) in primary rat Schwann cells. Cultured primary rat Schwann cells were randomly divided into five groups: blank control group (C group), H2 control group (H2 group), high osmotic control group (M group), high glucose …