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Lactulose-driven molecular hydrogen accelerates posthepatectomized liver regeneration

In Animal studies, Liver by CHESS

Oxidative stress and inflammation are implicated in the process of liver regeneration. Lactulose orally administered can be bacterially fermented and induces dramatic amounts of endogenous hydrogen. Hydrogen has been confirmed to have antioxidant and anti-inflammatory properties. This study investigated the potential influence of lactulose administration on liver regeneration. Antibiotics were used to suppress bacterial fermentation of lactulose, and hydrogen-rich saline …

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Hydrogen-rich saline with lactic acid alleviate myocardial reperfusion injury

In Animal studies, Cardiovascular by CHESS

This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd, and Lac + Hyd. The left coronary …

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Hydrogen-rich saline ameliorates acute lung injury

In Animal studies, Lung by CHESS

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. The experiments exhibited that gas exchange dysfunction and …