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Potential beneficial effects of hydrogen for ischemia-reperfusion injury in skeletal muscle

In Animal studies, Muscle by CHESS

The aim of this study was to investigate the potential beneficial effect of hydrogen-rich saline (HRS) in ischemia-reperfusion (IR) injury of skeletal muscle. Three experimental groups were established in male Sprague-Dawley rats: (1) sham group, (2) IR with normal saline group, (3) and IR with HRS group. A rat model of skeletal muscle IR injury was induced by 3-h tourniquet occlusion …

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Hydrogen-rich saline as a therapeutic agent for hematopoietic stem-cell transplantation

In Animal studies, Other studies by CHESS

Hydrogen, as a novel antioxidant, has been shown to selectively reduce the level of hydroxyl radicals and alleviate acute oxidative stress in many animal experiments. Hydrogen-rich saline provides a high concentration of hydrogen that can be easily and safely applied. Allogeneic hematopoietic stem-cell transplantation (HSCT) has been the most curative therapy for hematological malignancies. However, acute graft-versus-host disease (aGVHD) is …

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Hydrogen-rich saline alleviates inflammation induced by severe burn

In Animal studies, Inflammation by CHESS

Severe burns with delayed resuscitation are associated with high morbidity which is attributed to ischemia-reperfusion injury. This study was undertaken to investigate the effect of hydrogen-rich saline known as a significant selective antioxidant on the inflammatory reaction induced by severe burns with delayed resuscitation. By establishing the model of severe burns with delayed resuscitation in rats, we recorded improvement on …

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Injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury

In Animal studies, Gut by CHESS

Luminal preservation of the intestine is an attractive method to locally mitigate preservation injury and ischemic-reperfusion injury in small bowel transplantation (SBT) because this method has a potential to maintain the intestinal graft integrity. Hydrogen is noted as an antioxidant material by reducing hydroxyl radicals. Authors hypothesized that hydrogen-containing solution can be an optimum material for luminal preservation method in …