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Hydrogen-rich saline attenuating global cerebral ischemia-reperfusion injury

In Animal studies, Nervous system by CHESS

  The aim of this study was t investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats. Seventy-two male Sprague Dawley rats, weighing 280-320 g, were randomly divided into six groups (n = 12 each) : sham operation group (group I), cerebral ischemia-reperfusion group (group II), hydrogen-rich saline group (group III), …

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Hydrogen solution protects against intestinal injury

In Animal studies, Gut by CHESS

Intestinal tissue got largely decreased blood supply in uncontrolled hemorrhagic shock, because of limited blood mainly supporting brain, heart, kidney etc. This makes intestine as the primary injury target after uncontrolled hemorrhagic shock. However, limited studies focus on how to protect intestine against hemorrhagic shock. Ringer’s solution, pentoxifylline and hypertonic saline are widely used to resuscitate in haemorrhagic shock and …

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Effects of three hydrogen-rich liquids on lung injury-induced hemorrhagic shock

In Animal studies, Lung by CHESS

Hydrogen-rich saline provides a high concentration of hydrogen, which selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. Authors investigated the protective effects and mechanisms of three different hydrogen-rich liquid resuscitation preparations on lung injury-induced uncontrolled-hemorrhagic shock (UHS) in rats. A UHS rat model was prepared using the method of Capone et al. of arterial bleeding …