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Hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice

In Animal studies, Lung by CHESS

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, several studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H₂ ameliorates lung injury remain unclear. In the current study, authors investigated whether H₂ or …

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Molecular hydrogen and radiation protection

In Review papers by CHESS

Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-). It has been well-known that ionising radiation (IR) causes oxidative damage and consequent apoptosis mainly due to the production of •OH that follows radiolysis of H(2)O. Authors reported the protective effect of H(2) in irradiated cells and mice for the first time, …