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Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas

In Human studies, Metabolism by CHESS

Inhaling or ingesting hydrogen (H2) gas improves oxidative stress-induced damage in animal models and humans. It has been previously reported that H2 was consumed throughout the human body after the ingestion of H2-rich water and that the H2 consumption rate (VH2) was 1.0 μmol/min/m(2) body surface area. To confirm this result, authors evaluated VH2 during the inhalation of low levels …

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Molecular hydrogen exerts a regulating role in the release of pro- and anti-inflammatory cytokines

In In vitro studies by CHESS

Molecular hydrogen (H2) as a new medical gas has an anti-inflammatory effect. In the present study, authors investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. RAW 264.7 macrophages were stimulated by LPS (1 μg/mL) with presence or absence of different concentrations of H2. Cell viability and injury were tested by 3-(4,5)-dimethylthiahiazo …

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Protective effects of hydrogen-rich saline on ulcerative colitis

In Animal studies, Gut by CHESS

Ulcerative colitis (UC) is associated with enhanced production of reactive oxygen species and altered angiogenesis. Molecular hydrogen has been documented as a novel antioxidant to treat various reactive oxygen species-related diseases. The present study aimed to investigate the effects of hydrogen on UC using a rat model. UC in rats was induced with intracolonically administrated acetic acid. Hydrogen was supplied …

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Transperitoneal administration of hydrogen suppress peritoneal and systemic oxidative stress

In Human studies, Kidney by CHESS

Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS using albumin redox state as …