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Hydrogen therapy for acute radiation syndrome?

In Review papers by CHESS

Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H(2)) has antioxidant and antiapoptotic activities that protect the brain against ischemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the …

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Hydrogen resuscitation for cytoprotection

In Review papers by CHESS

Hydrogen is a colorless, odorless, tasteless and flammable gas. Hydrogen is considered a physiologically inert gas and is often used in deep-sea diving medicine. In mammals, endogenous hydrogen is produced as a result of the fermentation of non-digestible carbohydrates by intestinal bacteria and it is absorbed into the systemic circulation. Recent evidence indicates that hydrogen is a potent anti-oxidative, anti-apoptotic …

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Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative diseases

In Review papers by CHESS

Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson’s disease; ischemia/reperfusion …

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Hydrogen-rich water affected rate of acidosis induced by exercise in young healthy men

In Exercise, Human studies by CHESS

Metabolic acidosis is a clinical disturbance characterized by low pH in body tissues and blood and a variety of neuromuscular and cardiorespiratory responses. Besides treating the initial disorder, the main goal for patients with acidosis is to increase the systemic pH with alkalizing agents. The main aims of this study were to investigate whether daily oral administration of 2 L …

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Hydrogen-dissolved water inhibits growth of human tongue carcinoma cells

In In vitro studies by CHESS

Hydrogen-dissolved water (HD-water) or platinum nanocolloid (Pt-nc) has been individually expected as a new therapeutic agent for oxidative stress-related diseases, whereas little is known about their combined effects on cancer, which were elucidated in the present study. HD-water was prepared by microporous gas bubbling, and supplemented with Pt-nc consisting of 0.003-1 ppm Pt and PVP polymers. Antioxidant activities were examined …

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The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

In Animal studies, Cardiovascular by CHESS

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with …

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Hydrogen inhalation improves functional outcomes after cardiac arrest

In Animal studies, Cardiovascular by CHESS

All clinical and biological manifestations related to postcardiac arrest (CA) syndrome are attributed to ischemia-reperfusion injury in various organs including brain and heart. Molecular hydrogen (H(2)) has potential as a novel antioxidant. This study tested the hypothesis that inhalation of H(2) gas starting at the beginning of cardiopulmonary resuscitation (CPR) could improve the outcome of CA.¬†Ventricular fibrillation was induced by …

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Beneficial effect of hydrogen-rich saline on cerebral vasospasm after subarachnoid hemorrhage

In Animal studies, Cardiovascular by CHESS

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (¬∑OH) and ameliorate oxidative and inflammatory injuries to organs in many …

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Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts

In Animal studies, Cardiovascular by CHESS

Arterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties. We investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal hyperplasia. The inferior vena cava was excised, stored in cold Ringer solution for 2 h, and placed as an interposition graft …

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Hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia

In Animal studies, Cardiovascular by CHESS

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent studies have suggested that hydrogen (H(2)) may have an antioxidant effect by reducing hydroxyl radicals. In this study, we investigated the effects of …